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Clonal heterogeneity at allelic methylation sites diagnostic for Prader–Willi and Angelman syndromes

Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are developmental disorders resulting from the absence of the paternal or maternal contribution to the 15q11–13 region, respectively. Allele-specific methylation at D15S63 (PW71) has routinely been used as a diagnostic indicator of PWS and AS in...

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Detalhes bibliográficos
Main Authors: LaSalle, Janine M., Ritchie, Rachael J., Glatt, Heather, Lalande, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19144/
https://ncbi.nlm.nih.gov/pubmed/9465075
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