In Vivo-Selected Mutations in Methyl-Directed Mismatch Repair Suppress the Virulence Attenuation of Salmonella dam Mutant Strains following Intraperitoneal, but Not Oral, Infection of Naïve Mice

Salmonella enterica serovar Typhimurium that lacks the DNA adenine methylase (Dam) ectopically expresses multiple genes that are preferentially expressed during infection, is attenuated for virulence, and confers heightened immunity in vaccinated hosts. The safety of dam mutant Salmonella vaccines w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Heithoff, Douglas M., Badie, Golnaz, Julio, Steven M., Enioutina, Elena Y., Daynes, Raymond A., Sinsheimer, Robert L., Mahan, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Molecular Biology of Pathogens
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913454/
https://ncbi.nlm.nih.gov/pubmed/17468250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00299-07
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge