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In Vivo-Selected Mutations in Methyl-Directed Mismatch Repair Suppress the Virulence Attenuation of Salmonella dam Mutant Strains following Intraperitoneal, but Not Oral, Infection of Naïve Mice
Salmonella enterica serovar Typhimurium that lacks the DNA adenine methylase (Dam) ectopically expresses multiple genes that are preferentially expressed during infection, is attenuated for virulence, and confers heightened immunity in vaccinated hosts. The safety of dam mutant Salmonella vaccines w...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913454/ https://ncbi.nlm.nih.gov/pubmed/17468250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00299-07 |
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