Multiple-Dose Escalation Study of the Safety, Pharmacokinetics, and Biologic Activity of Oral AMD070, a Selective CXCR4 Receptor Inhibitor, in Human Subjects

AMD070 is an oral CXCR4 antagonist with in vitro activity against X4-tropic human immunodeficiency virus type 1. Thirty fasting healthy male volunteers received oral doses of AMD070 ranging from a single 50-mg dose to seven 400-mg doses given every 12 h (q12h). Nine subjects received a 200-mg dose d...

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Hauptverfasser: Stone, Nimalie D., Dunaway, Shelia B., Flexner, Charles, Tierney, Camlin, Calandra, Gary B., Becker, Stephen, Cao, Ying-Jun, Wiggins, Ilene P., Conley, Jeanne, MacFarland, Ron T., Park, Jeong-Gun, Lalama, Christina, Snyder, Sally, Kallungal, Beatrice, Klingman, Karin L., Hendrix, Craig W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2007
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913234/
https://ncbi.nlm.nih.gov/pubmed/17452489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00013-07
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