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Nav Channel Mechanosensitivity: Activation and Inactivation Accelerate Reversibly with Stretch
Voltage-gated sodium channels (Nav) are modulated by many bilayer mechanical amphiphiles, but whether, like other voltage-gated channels (Kv, HCN, Cav), they respond to physical bilayer deformations is unknown. We expressed human heart Nav1.5 pore α-subunit in oocytes (where, unlike αNav1.4, αNav1.5...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913161/ https://ncbi.nlm.nih.gov/pubmed/17496023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.101246 |
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