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Nav Channel Mechanosensitivity: Activation and Inactivation Accelerate Reversibly with Stretch

Voltage-gated sodium channels (Nav) are modulated by many bilayer mechanical amphiphiles, but whether, like other voltage-gated channels (Kv, HCN, Cav), they respond to physical bilayer deformations is unknown. We expressed human heart Nav1.5 pore α-subunit in oocytes (where, unlike αNav1.4, αNav1.5...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Morris, Catherine E., Juranka, Peter F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913161/
https://ncbi.nlm.nih.gov/pubmed/17496023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.101246
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