Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation.

EBNA2 is essential for immortalization of B cells by Epstein-Barr virus. EBNA2 is tethered to responsive promoters through a cellular factor, CBF1. CBF1 also binds to the activated form of mammalian Notch1, providing a linkage between EBNA2 function and Notch signalling. However, Notch2 is the predo...

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Publié dans:	J Virol
Auteurs principaux:	Hsieh, J J, Nofziger, D E, Weinmaster, G, Hayward, S D
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191274/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032325/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.1938-1945.1997
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