Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1.

The reovirus attachment protein, sigma1, determines numerous aspects of reovirus-induced disease, including viral virulence, pathways of spread, and tropism for certain types of cells in the central nervous system. The sigma1 protein projects from the virion surface and consists of two distinct morp...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Chappell, J D, Gunn, V L, Wetzel, J D, Baer, G S, Dermody, T S
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191253/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032313/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.1834-1841.1997
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