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The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection.

Adeno-associated virus (AAV) uses three promoters, p5, p19, and p40, to regulate viral gene expression. The p5 and p19 promoters direct the synthesis of the viral regulatory proteins, Rep78 and -68 and Rep52 and -40, respectively. The p5 Rep proteins bind a linear 22-bp sequence, the Rep binding ele...

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Udgivet i:J Virol
Principais autores: Pereira, D J, McCarty, D M, Muzyczka, N
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191159/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8995628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.2.1079-1088.1997
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