Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ.

Based on the hypothesis that tissue macrophages present an obstacle for adenovirus (Ad) vector-mediated gene transfer to internal organs, this study evaluated the consequences of transient depletion of Kupffer cells on subsequent transfer of the Ad vector genome and Ad vector-directed gene expressio...

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Dettagli Bibliografici

Pubblicato in:	J Virol
Autori principali:	Wolff, G, Worgall, S, van Rooijen, N, Song, W R, Harvey, B G, Crystal, R G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191093/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8985392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.1.624-629.1997
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