The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase.

The 2A proteinases (2Apro) of certain picornaviruses induce the cleavage of the eIF4G subunit of the cap-binding protein complex, eIF4F. Several reports have demonstrated that 2Apro of rhinovirus and coxsackievirus B4 cleave eIF4G directly. However, it was suggested that in poliovirus infection, the...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Haghighat, A, Svitkin, Y, Novoa, I, Kuechler, E, Skern, T, Sonenberg, N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190934/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8444-8450.1996
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