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Selective blockade of M2 and M3 muscarinic receptors by hexahydrobenzyl-fourdapine and a comparison with zamifenacin.

1. 4-Diphenylacetoxy-N-cyclohexylmethyl-piperidine HCl (hexahydro-benz-4DAP) is more active as an antagonist of carbachol at receptors in guinea-pig isolated ileum, log K (pA2) = 6.64 +/- 0.14 (s.e. 7 results), than at receptors in guinea-pig isolated atria, log K = 5.43 +/- 0.14 (7). In the presenc...

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Bibliografische gegevens
Hoofdauteurs: Barlow, R. B., Bond, S. M., Branthwaite, A. G., Jackson, O., McQueen, D. S., Smith, K. M., Smith, P. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1995
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1909210/
https://ncbi.nlm.nih.gov/pubmed/8680722
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