RS-45041-190: a selective, high-affinity ligand for I2 imidazoline receptors.

1. RS-45041-190 (4-chloro-2-(imidazolin-2-yl)isoindoline) showed high affinity for I2 imidazoline receptors labelled by [3H]-idazoxan in rat (pKi = 8.66 +/- 0.09), rabbit (pKi = 9.37 +/- 0.07), dog (pKi = 9.32 +/- 0.18) and baboon kidney (pKi = 8.85 +/- 0.12), but had very low affinity for alpha 2-a...

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Main Authors: Brown, C. M., MacKinnon, A. C., Redfern, W. S., Williams, A., Linton, C., Stewart, M., Clague, R. U., Clark, R., Spedding, M.
Formato: Artigo
Idioma:Inglês
Publicado: 1995
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1909080/
https://ncbi.nlm.nih.gov/pubmed/8528553
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