Mutations in active-site residues of the uracil-DNA glycosylase encoded by vaccinia virus are incompatible with virus viability.

The D4R gene of vaccinia virus encodes a functional uracil-DNA glycosylase that is essential for viral viability (D. T. Stuart, C. Upton, M. A. Higman, E. G. Niles, and G. McFadden, J. Virol. 67:2503-2513, 1993), and a D4R mutant, ts4149, confers a conditional lethal defect in viral DNA replication...

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Publicat a:	J Virol
Autors principals:	Ellison, K S, Peng, W, McFadden, G
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1996
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190869/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8892920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.11.7965-7973.1996
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