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Rotavirus VP1 alone specifically binds to the 3' end of viral mRNA, but the interaction is not sufficient to initiate minus-strand synthesis.
Recent studies have shown that disrupted (open) rotavirus cores have an associated replicase activity which supports the synthesis of dsRNA from viral mRNA in a cell-free system (D. Chen, C. Q.-Y. Zeng, M. J. Wentz, M. Gorziglia, M. K. Estes, and R. F. Ramig, J. Virol. 68:7030-7039, 1994). To determ...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1996
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC190866/ https://ncbi.nlm.nih.gov/pubmed/8892917 |
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