Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT(2) receptor antagonist

1 RP 62203 (2-[3-(4-(4-fluorophenyl)-piperazinyl)propyl]naphto[1,8-cd]isothiazole-1, 1-dioxide) is a novel naphtosultam derivative which shows very high affinity for 5-HT(2) receptors in the rat cerebral cortex (K(i) = 50.0 pM). 2 RP 62203 is relatively selective for this sub-type of 5-hydroxytrypta...

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Auteurs principaux: Doble, A., Girdlestone, D., Piot, O., Allam, D., Betschart, J., Boireau, A., Dupuy, A., Guérémy, C., Ménager, J., Zundel, J.L., Blanchard, J.C.
Format: Artigo
Langue:Inglês
Publié: 1992
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Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908636/
https://ncbi.nlm.nih.gov/pubmed/1596688
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