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The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI-988.

The ability of a selective cholecystokininB (CCKB) receptor antagonist, CI-988, to block benzodiazepine withdrawal effects was examined in mice. The discontinuation of twice daily administration of diazepam (1 mg kg-1, i.p.) induced withdrawal anxiogenesis and a proconvulsant effect. In contrast, no...

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Main Authors: Singh, L., Field, M. J., Vass, C. A., Hughes, J., Woodruff, G. N.
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908629/
https://ncbi.nlm.nih.gov/pubmed/1350747
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