Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including m...

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Bibliographic Details
Main Authors: Beresford, I. J., Birch, P. J., Hagan, R. M., Ireland, S. J.
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908580/
https://ncbi.nlm.nih.gov/pubmed/1665729
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