Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.

1. Whole-cell, patch-clamp recordings from cultured hippocampal neurones have been used to characterize the action of the GABAA ligand, 5-(4-piperidyl)isoxazol-3-ol (4-PIOL). The action of 4-PIOL was compared with that of the established GABAA agonist, isoguvacine. 2. With a symmetrical Cl- gradient...

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Bibliographic Details
Main Authors: Kristiansen, U., Lambert, J. D., Falch, E., Krogsgaard-Larsen, P.
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908300/
https://ncbi.nlm.nih.gov/pubmed/1664767
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