The pharmacology of RS-15385-197, a potent and selective α(2)-adrenoceptor antagonist

1 RS-15385-197 ((8aR, 12aS, 13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsul- phonyl)-6H-isoquino [2,1-g][1,6]-naphthyridine) was evaluated in a series of in vitro and in vivo tests as an antagonist at α(2)-adrenoceptors. 2 RS-15385-197 had a pK(i) of 9.45 for α(2)-adrenoceptors...

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Main Authors: Brown, C.M., MacKinnon, A.C., Redfern, W.S., Hicks, P.E., Kilpatrick, A.T., Small, C., Ramcharan, M., Clague, R.U., Clark, R.D., MacFarlane, C.B., Spedding, M.
Format: Artigo
Language:Inglês
Published: 1993
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1908001/
https://ncbi.nlm.nih.gov/pubmed/8095420
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