Non-specific activity of (+/-)-CP-96,345 in models of pain and inflammation.

The non-peptide NK1 receptor antagonist, CP-96,345, and its 2R,3R enantiomer CP-96,344, which is not an NK1 receptor antagonist (IC50 > 10 microM), were evaluated for antinociceptive and anti-inflammatory activities in several classical models of pain and inflammation in the rat. Both CP-96,345 a...

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Main Authors: Nagahisa, A., Asai, R., Kanai, Y., Murase, A., Tsuchiya-Nakagaki, M., Nakagaki, T., Shieh, T. C., Taniguchi, K.
Formato: Artigo
Idioma:Inglês
Publicado: 1992
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907865/
https://ncbi.nlm.nih.gov/pubmed/1330170
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