Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways.

1. SDZ PCO 400 evoked dose-related relaxation of isolated airway smooth muscle. For human bronchus precontracted by endogenous tone or addition of carbachol (10(-5) M), IC50 values were 1.74 microM and 1.82 microM respectively. With guinea-pig trachea contracted by endogenous tone, a comparable IC50...

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Detalhes bibliográficos
Main Authors: Chapman, I. D., Kristersson, A., Mathelin, G., Schaeublin, E., Mazzoni, L., Boubekeur, K., Murphy, N., Morley, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907487/
https://ncbi.nlm.nih.gov/pubmed/1382782
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