Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model

Transforming growth factor-β (TGF-β) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling TGF-β activity in gliomas is to disrupt the signaling cascade at the level of the TGF-β receptor I (TGF-βRI) kinase, thu...

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Detalhes bibliográficos
Main Authors: Tran, Thomas-Toan, Uhl, Martin, Ma, Jing Ying, Janssen, Lisa, Sriram, Venkataraman, Aulwurm, Steffen, Kerr, Irene, Lam, Andrew, Webb, Heather K., Kapoun, Ann M., Kizer, Darin E., McEnroe, Glenn, Hart, Barry, Axon, Jonathan, Murphy, Alison, Chakravarty, Sarvajit, Dugar, Sundeep, Protter, Andrew A., Higgins, Linda S., Wick, Wolfgang, Weller, Michael, Wong, Darren H.
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2007
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907409/
https://ncbi.nlm.nih.gov/pubmed/17522330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-010
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