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Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis
The MutY homolog (MYH) can excise adenines misincorporated opposite to guanines or 7, 8-dihydro-8-oxo-guanines (8-oxoG) during DNA replication; thereby preventing G:C to T:A transversions. Germline mutations in the human MYH gene are associated with recessive inheritance of colorectal adenomatous po...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1907362/ https://ncbi.nlm.nih.gov/pubmed/17081686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2006.09.016 |
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