Loading...

Heteroduplex Formation in SMN Gene Dosage Analysis

Most spinal muscular atrophy patients lack both copies of SMN1 exon 7 and most carriers have only one copy of SMN1 exon 7. We investigated the effect of SMN1/SMN2 heteroduplex formation on SMN gene dosage analysis, which is an assay to determine copy number of SMN1 exon 7 that utilizes multiplex qua...

Full description

Saved in:
Bibliographic Details
Main Authors: Ogino, Shuji, Leonard, Debra G. B., Rennert, Hanna, Gao, Sizhen, Wilson, Robert B.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2001
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906961/
https://ncbi.nlm.nih.gov/pubmed/11687598
Tags: Add Tag
No Tags, Be the first to tag this record!