Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV

Zidovudine-based antiretroviral therapies (ART) for treatment of HIV-infected pregnant women have markedly reduced mother-to-child transmission of the human immunodeficiency virus (HIV-1) from ~25% to <1%. However, zidovudine (ZDV; AZT), a nucleoside analogue, induces chromosomal damage, gene mut...

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Main Authors: Witt, Kristine L., Cunningham, Coleen K., Patterson, Kristine B., Kissling, Grace E., Dertinger, Stephen D., Livingston, Elizabeth, Bishop, Jack B.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906863/
https://ncbi.nlm.nih.gov/pubmed/17358032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20266
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