Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis

Autoantibodies to 65 kDa glutamic acid decarboxylase (GAD65) are produced in many patients with autoimmune polyendocrine syndrome type II (APS-II) or stiff-man syndrome (SMS) and are heterogeneous in their epitope specificities, recognizing both conformational and linear determinants. Major linear e...

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Bibliographische Detailangaben
Hauptverfasser: AL-BUKHARI, T A M A, RADFORD, P M, BOURAS, G, DAVENPORT, C, TRIGWELL, S M, BOTTAZZO, G-F, LAI, M, SCHWARTZ, H L, TIGHE, P J, TODD, I
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2002
Schlagworte:
Clinical Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906485/
https://ncbi.nlm.nih.gov/pubmed/12296864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2002.01960.x
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