Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus

The generation of an autoimmune response against islet beta-cells is central to the pathogenesis of type 1 diabetes mellitus, and this response is driven by the stimulation of autoreactive lymphocytes by components of the beta-cells themselves. Reactive oxygen species (ROS) have been implicated in t...

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Detalhes bibliográficos
Main Authors: Trigwell, S M, Radford, P M, Page, S R, Loweth, A C, James, R F L, Morgan, N G, Todd, I
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Renal Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906190/
https://ncbi.nlm.nih.gov/pubmed/11703367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01653.x
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