Lack of age-associated LFA-1 up-regulation and impaired ICAM-1 binding in lymphocytes from patients with Down syndrome

To investigate the role of LFA-1 in the immune defects in DS patients, we analysed lymphocytes from DS patients in LFA-1 expression and LFA-1 mediated cell adhesion. DS patients less than 2 years of age expressed a higher level of LFA-1 when compared with age-matched controls. The difference in LFA-...

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Main Authors: Lin, S-J, Wang, J-Y, Klickstein, L B, Chuang, K-P, Chen, J-Y, Lee, J-F, Shieh, C-C
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2001
Fag:
Human Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906165/
https://ncbi.nlm.nih.gov/pubmed/11678899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01660.x
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