Inosine monophosphate dehydrogenase (IMPDH) inhibition in vitro suppresses lymphocyte proliferation and the production of immunoglobulins, autoantibodies and cytokines in splenocytes from MRLlpr/lpr mice

The aim of this study was to evaluate the effects of the immunomodulating drug mycophenolic acid (MPA) on splenocytes in an animal model of systemic lupus erythematosus (SLE), using MRLlpr/lpr mice. MPA reversibly inhibits inosine 5′-monophosphate dehydrogenase, an enzyme involved in the de novo gua...

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Autors principals: Jonsson, C A, Carlsten, H
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
Matèries:
Immunity to Infection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906074/
https://ncbi.nlm.nih.gov/pubmed/11472413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01545.x
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