Non FcR-binding murine antihuman CD3 monoclonal antibody is capable of productive TCR signalling and induces proliferation in the presence of costimulation

CLB T3/4.A is a non FcR-binding CD3 mAb of the murine IgA isotype, which may be used as an alternative for the mitogenic OKT3 mAb in the treatment of acute cellular rejection after organ transplantation. We studied TCR signalling and T cell activation in response to T3/4.A in normal human PBMC in vi...

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Detalhes bibliográficos
Main Authors: Meijer, R T, Yong, S L, Ten Berge, I J M, Van Lier, R A W, Schellekens, P T A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
T Lymphocyte Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905998/
https://ncbi.nlm.nih.gov/pubmed/11298141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2001.01464.x
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