The N terminus of the serpin, tengpin, functions to trap the metastable native state

Serpins fold to a metastable native state and are susceptible to undergoing spontaneous conformational change to more stable conformers, such as the latent form. We investigated conformational change in tengpin, an unusual prokaryotic serpin from the extremophile Thermoanaerobacter tengcongensis. In...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhang, Qingwei, Buckle, Ashley M, Law, Ruby H P, Pearce, Mary C, Cabrita, Lisa D, Lloyd, Gordon J, Irving, James A, Smith, A Ian, Ruzyla, Katya, Rossjohn, Jamie, Bottomley, Stephen P, Whisstock, James C
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2007
Sujets:
Scientific Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905895/
https://ncbi.nlm.nih.gov/pubmed/17557112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400986
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