Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom

Envenoming by the Brazilian pit viper, Bothrops jararaca, induces extensive local and systemic haemorrhage in humans. The severe and occasionally lethal outcome of envenoming is prevented only by administration of antivenom which is conventionally prepared by hyperimmunization of large animals with...

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Dettagli Bibliografici
Autori principali: Harrison, R A, Moura-Da-Silva, A M, Laing, G D, Wu, Y, Richards, A, Broadhead, A, Bianco, A E, Theakston, R D G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2000
Soggetti:
Immunotoxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905716/
https://ncbi.nlm.nih.gov/pubmed/10931154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01287.x
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