Construction of a water-soluble form of penicillin-binding protein 2a from a methicillin-resistant Staphylococcus aureus isolate.

The mecA gene from methicillin-resistant Staphylococcus aureus 27r, which encodes the membrane-bound penicillin-binding protein 2a (PBP 2a), was cloned, sequenced, and expressed in Escherichia coli. PBP 2a is the major factor that mediates methicillin resistance in staphylococci. The DNA sequence of...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Wu, C Y, Hoskins, J, Blaszczak, L C, Preston, D A, Skatrud, P L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190552/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1622161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.3.533
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