Interferon-alpha (IFN-α) enhances cytotoxicity in healthy volunteers and chronic hepatitis C infection mainly by the perforin pathway

Cell-mediated cytotoxicity is exerted via perforin and Fas ligand (FasL). We have recently shown that IFN-α up-regulates FasL expression in T cells isolated from healthy volunteers and augments activation-induced T cell death. Since the Fas/FasL system is implicated in the pathogenesis of hepatic fa...

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Detalhes bibliográficos
Main Authors: Kaser, A, Enrich, B, Ludwiczek, O, Vogel, W, Tilg, H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905394/
https://ncbi.nlm.nih.gov/pubmed/10540162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.01020.x
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