Conformationally altered β(2)-glycoprotein I is the antigen for anti-cardiolipin autoantibodies

Anti-cardiolipin autoantibodies (aCL) induce thrombosis and recurrent fetal death. These antibodies require a ‘cofactor’, identified as β(2)-glycoprotein I (β(2)-GPI), to bind phospholipids. We show here that aCL can bind β(2)-GPI in the absence of phospholipid. Binding of aCL to β(2)-GPI is depende...

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Detalhes bibliográficos
Main Authors: Chamley, L W, Duncalf, A M, Konarkowska, B, Mitchell, M D, Johnson, P M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905254/
https://ncbi.nlm.nih.gov/pubmed/10193436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00810.x
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