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Conformationally altered β(2)-glycoprotein I is the antigen for anti-cardiolipin autoantibodies
Anti-cardiolipin autoantibodies (aCL) induce thrombosis and recurrent fetal death. These antibodies require a ‘cofactor’, identified as β(2)-glycoprotein I (β(2)-GPI), to bind phospholipids. We show here that aCL can bind β(2)-GPI in the absence of phospholipid. Binding of aCL to β(2)-GPI is depende...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1905254/ https://ncbi.nlm.nih.gov/pubmed/10193436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00810.x |
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