C1q, a subunit of the first component of complement, enhances antibody-mediated apoptosis of cultured rat glomerular mesangial cells

We have shown previously that IgG2a anti-Thy-1 MoAb (ER4G) induces apoptosis of rat mesangial cells (GMC) in vitro. Since the classical complement pathway plays an essential role in Thy-1 nephritis, we analysed whether C1q, a subunit of the first component of complement, enhances the ER4G-mediated a...

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Detalhes bibliográficos
Main Authors: SATO, T, VAN DIXHOORN, M G A, HEEMSKERK, E, VAN ES, L A, DAHA, M R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1997
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904760/
https://ncbi.nlm.nih.gov/pubmed/9328130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1997.4741372.x
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