Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.

Retroviral reverse transcription starts near the 5' end of unspliced viral RNA at a sequence called the primer binding site (PBS), where the tRNA primer anneals to the RNA template for initiation of DNA synthesis. We have investigated the roles of NCp7 in annealing of primer tRNA(Lys3) to the PBS an...

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Publié dans:	J Virol
Auteurs principaux:	Li, X, Quan, Y, Arts, E J, Li, Z, Preston, B D, de Rocquigny, H, Roques, B P, Darlix, J L, Kleiman, L, Parniak, M A, Wainberg, M A
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8764006/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.8.4996-5004.1996
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