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Snake-venom-derived Factor IX-binding protein specifically blocks the γ-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X

A potent anticoagulant protein, IX-bp (Factor IX binding protein), has been isolated from the venom of Trimeresurus flavoviridis (habu snake) and is known to bind specifically to the Gla (γ-carboxyglutamic acid-rich) domain of Factor IX. To evaluate the molecular basis for its anticoagulation activi...

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Autors principals: Gopinath, Subash C. B., Shikamoto, Yasuo, Mizuno, Hiroshi, Kumar, Penmetcha K. R.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904519/
https://ncbi.nlm.nih.gov/pubmed/17407444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061737
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