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Murine coronavirus membrane fusion is blocked by modification of thiols buried within the spike protein.

The envelopes of murine hepatitis virus (MHV) particles are studded with glycoprotein spikes that function both to promote virion binding to its cellular receptor and to mediate virion-cell membrane fusion. In this study, the cysteine-rich spikes were subjected to chemical modification to determine...

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Bibliographic Details
Published in:J Virol
Main Author: Gallagher, T M
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1996
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190404/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8676494/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.7.4683-4690.1996
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