Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.

5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid was prepared from rabbit neutrophils challenged with ionophore A23187 plus arachidonic acid. It was purified by reverse-phase high-performance liquid chromatography with the use of a two-step procedure that effectively resolved the lipid from closely el...

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Autores principales: O'Flaherty, J. T., Wykle, R. L., Lees, C. J., Shewmake, T., McCall, C. E., Thomas, M. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1981
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1903896/
https://ncbi.nlm.nih.gov/pubmed/6274199
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