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The role of gamma-glutamyl transpeptidase in the nephrotoxicity of an Agaricus bisporus metabolite.

The mushroom metabolite gamma-L-glutaminyl-3,4-dihydroxybenzene (GDHB) was found to have an LD50 of 100 to 200 mg/kg in neonatal C57Bl/6J mice. Adult mice given 200 mg/kg GDHB showed histopathologic evidence of proximal convoluted tubular injury as early as 2 hours after injection, which progressed...

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Détails bibliographiques
Auteurs principaux: Boekelheide, K., Graham, D. G., Mize, P. D., Vogel, F. S.
Format: Artigo
Langue:Inglês
Publié: 1980
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1903552/
https://ncbi.nlm.nih.gov/pubmed/6106387
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