Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma

BACKGROUND: N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens. Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. I...

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Detalhes bibliográficos
Main Authors: Mahid, Suhal S, Colliver, Daniel W, Crawford, Nigel PS, Martini, Benjamin D, Doll, Mark A, Hein, David W, Cobbs, Gary A, Petras, Robert E, Galandiuk, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1903350/
https://ncbi.nlm.nih.gov/pubmed/17537267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-8-28
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