High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation.

We report here that in the rabbit ocular model of herpes simplex virus type 1 (HSV-1) latency, spontaneous reactivation of the HSV-1 ICP34.5 deletion mutant d34.5 increased significantly in response to increasing infectious doses. At the highest infectious dose of d34.5, the spontaneous reactivation...

Полное описание

Библиографические подробности

Опубликовано в::	J Virol
Главные авторы:	Perng, G C, Ghiasi, H, Slanina, S M, Nesburn, A B, Wechsler, S L
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1996
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190146/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627763/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.5.2883-2893.1996
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