Mutational analysis of the vaccinia virus E3 protein defines amino acid residues involved in E3 binding to double-stranded RNA.

Alanine-substitution mutations were targeted to 14 amino acid residues within the double-stranded (ds) RNA binding motif (dsRBM) of the vaccinia virus E3 protein. Substitutions at six positions--Glu-124, Phe-135, Phe-148, Lys-167, Arg-168, and Lys-171--caused significant reductions in dsRNA binding....

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Ho, C K, Shuman, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8642694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.4.2611-2614.1996
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