Novel Nuclear Import of Vpr Promoted by Importin α Is Crucial for Human Immunodeficiency Virus Type 1 Replication in Macrophages

Monocytes/macrophages are major targets of human immunodeficiency virus type 1 (HIV-1) infection. The viral preintegration complex (PIC) of HIV-1 enters the nuclei of monocyte-derived macrophages, but very little PIC migrates into the nuclei of immature monocytes. Vpr, one of the accessory gene prod...

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Autori principali: Nitahara-Kasahara, Yuko, Kamata, Masakazu, Yamamoto, Takuya, Zhang, Xianfeng, Miyamoto, Yoichi, Muneta, Koho, Iijima, Sayuki, Yoneda, Yoshihiro, Tsunetsugu-Yokota, Yasuko, Aida, Yoko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900242/
https://ncbi.nlm.nih.gov/pubmed/17344301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01928-06
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