Smad7 Antagonizes Transforming Growth Factor β Signaling in the Nucleus by Interfering with Functional Smad-DNA Complex Formation

Smad7 plays an essential role in the negative-feedback regulation of transforming growth factor β (TGF-β) signaling by inhibiting TGF-β signaling at the receptor level. It can interfere with binding to type I receptors and thus activation of receptor-regulated Smads or recruit the E3 ubiquitin ligas...

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Main Authors: Zhang, Suping, Fei, Teng, Zhang, Lixia, Zhang, Ran, Chen, Feng, Ning, Yuanheng, Han, Yuna, Feng, Xin-Hua, Meng, Anming, Chen, Ye-Guang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900056/
https://ncbi.nlm.nih.gov/pubmed/17438144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01636-06
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