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Gut-Enriched Krüppel-Like Factor Interaction with Smad3 Inhibits Myofibroblast Differentiation

Gut-enriched Krüppel-like factor (GKLF) has been reported to partially inhibit α-smooth muscle actin (α-SMA) gene transcription by competing for binding to the TGF-β control element (TCE) with known activators such as Sp1 and other Krüppel-like factors. This incomplete inhibition via the TCE suggest...

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Autors principals: Hu, Biao, Wu, Zhe, Liu, Tianju, Ullenbruch, Matthew R., Jin, Hong, Phan, Sem H.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899300/
https://ncbi.nlm.nih.gov/pubmed/16858008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0043OC
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