Both the changes of six amino acids and the C-terminal truncation caused by a one-base insertion in the defective env gene of Friend spleen focus-forming virus significantly affect the pathogenic activity of the encoded leukemogenic membrane glycoprotein (gp55).

Friend spleen focus-forming virus (F-SFFV) causes acute erythroleukemia in mice and encodes in its defective env gene an Env-like membrane glycoprotein (gp55). The F-SFFV env gene has three characteristic structures compared with that of ecotropic murine leukemia viruses (MuLVs): substitution by the...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Watanabe, N, Yugawa, T, Ikawa, Y, Amanuma, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189700/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7494268/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.12.7606-7611.1995
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