Role of serum amyloid P component in bacterial infection: Protection of the host or protection of the pathogen

Serum amyloid P component (SAP) binds to Streptococcus pyogenes, and we show here that it also binds to Neisseria meningitidis, including a lipopolysaccharide (LPS)-negative mutant, and to rough variants of Escherichia coli. Surprisingly, this binding had a powerful antiopsonic effect both in vitro...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Noursadeghi, Mahdad, Bickerstaff, Maria C. M., Gallimore, J. Ruth, Herbert, Jeff, Cohen, Jonathan, Pepys, Mark B.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14584
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