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Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog
African sleeping sickness is a fatal disease that is caused by the protozoan parasite Trypanosoma brucei. Polyamine biosynthesis is an essential pathway in the parasite and is a validated drug target for treatment of the disease. S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes a key step in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895940/ https://ncbi.nlm.nih.gov/pubmed/17485680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701111104 |
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